According to survey data, the two largest MDMA consumer markets per capita in the European Union are the Netherlands and Ireland, with 6 % or more people aged 15 to 34 reporting to have consumed MDMA in the last year. Some of the high-strength ecstasy tablets are scored to allow consumers to divide them into smaller portions. These identifications of high-strength ecstasy tablets prompted harm reduction organisations to issue alerts. In December 2023, beige-golden ecstasy pills with an Audi-logo containing over 300 milligrams of MDMA (between 316 and 324 milligrams) were submitted to drug testing in the Netherlands (DIMS, 2023). However, this trend appears to be changing, as ecstasy tablets have tended to contain less MDMA since 201 The subsequent drop in MDMA content in tablets since 2019 does not appear to have been accompanied by a significant drop in price. In 2021, adult respondents to the EWSD reported paying a median of EUR 7.20 per ecstasy tablet and a median of EUR 37.40 per gram for MDMA powder. (a) In clinical trials, doses of MDMA capable of producing subjective effects vary from 1.5 to 1.7 mg/kg of body weight, or approximately 105 to 119 milligrams for a 70-kilogram individual. Harm reduction responses, including the provision of drug-checking services and appropriate risk-communication strategies, are crucial to minimise these risks. Some tablets even contain stamping that indicate the quantity of MDMA present, although this is not always accurate and may also constitute a health risk. For example, in August 2023, tablets containing 350 milligrams of MDMA were seized in Spain. Tuci or tucibi (also spelled tusi and [[https://royalmedspharma.com/global-mdma-ecstasy-market-trends-and-insights/|mdma for sale online]] tusibi) are phonetic transliterations of ‘2C’ (a series of psychoactive phenethylamines) or ‘2C-B’ (one of the most well-known derivatives of that series of substances). The detection of mixtures of MDMA and ketamine combined with other substances including cocaine have also increased in some regions of Europe, and are sold as ‘pink cocaine’, ‘tuci’ or ‘tucibi’ (see Box 6.3. What is tucibi?). These signals were reported to the EU Early Warning System from 2022 onwards, based on identifications occurring in Spain, the Netherlands and Austria, and there are similar indications for the United Kingdom (Pascoe et al., 2022). Interestingly, synthesis by-products were also commonly reported, about which little is known and which may pose additional risks to consumers. A number of substances can also be sold as MDMA, in what is sometimes called mis-selling or adulteration by substitution – whereby another substance is passed off as MDMA to the consumer. Da Adulteration of MDMA occurs by adding other psychoactive substances, typically stimulants, to MDMA in tablet, powder or crystal form. PMK glycidate, first reported in Europe in 2013, had a particular role in this resurgence (see Section Production - designer precursors substitute scheduled MDMA starting materials). In 2009 and the following years, it was therefore unlikely that consumers who purchased ecstasy in Europe would obtain unadulterated MDMA. In 2009, on average, only 31 % of the tablets analysed contained MDMA alone, compared with almost 100 % in 2004. This includes law enforcement pressure, a variety of factors affecting MDMA production, such as the availability of MDMA precursors, and, more generally, globalisation of the illicit drug supply chain In fact, it could be argued that MDMA in the form of ecstasy tablets became cheaper between 2012 and 2019 as tablets containing larger quantities of MDMA became increasingly available on the market (see Section The trend of large tablets containing more MDMA may be reversing The majority of these identifications were reported by Spain, although pink powders have also been reported in Czechia, Germany, Estonia, Hungary, the Netherlands, Austria, Poland, Romania, Sweden and Norway. However, mdma for sale online from 2019 onwards, the quantity of MDMA found in tablets appears to have slightly decreased. However, larger seizures of these mixtures have also been reported in the European Union. These detections have generally been small in quantity with the powders containing a range of different substances – always ketamine and MDMA, and typically additional substances including cocaine, caffeine or cathinones. The majority of these identifications were reported by Spain, although pink powders have also been reported in Czechia, Germany, Estonia, Hungary, the Netherlands, Austria, Poland, Romania, Sweden and Norway. Throughout 2021, and continuing into 2022 and 2023, a number of detections of pink powders consistent with tucibi were reported to the EU Early Warning System. Tuci or tucibi products can also be sold under the name ‘pink cocaine’ despite rarely containing 2C-type phenethylamines or cocaine. Wastewater-based methods The use of these methods differed between countries, indicating that some purchasing practices are more common in some countries than in others. Smaller numbers of respondents also reported using the darknet (13 %) and social media (7 %). Data from drug-checking services can also inform on the type of relationships that exist between the consumer and the provider. The products had a net weight of approximately 20 grams each and contained between 130 and 176 milligrams of MDMA, evenly distributed inside the lollipops. Increased ener